GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9309473 | 1 | rs6546838 | chr2:73679280 | ALMS1P | chr2:73872046-73912692:+ | 0.71 | 11.27 | 2.76E-26 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546838 | chr2:73679280 | NAT8 | chr2:73867850-73869537:- | 0.38 | 6.02 | 3.55E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546838 | chr2:73679280 | TPRKB | chr2:73956957-73964517:- | -0.17 | -4.38 | 1.45E-5 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546839 | chr2:73680508 | ALMS1P | chr2:73872046-73912692:+ | 0.69 | 11 | 2.99E-25 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546839 | chr2:73680508 | NAT8 | chr2:73867850-73869537:- | 0.37 | 5.87 | 8.35E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546839 | chr2:73680508 | TPRKB | chr2:73956957-73964517:- | -0.17 | -4.23 | 2.82E-5 | Metabolite levels |
| THCA | cis | rs6547705 | 1 | rs6547705 | chr2:87044316 | LOC285074 | chr2:87257799-87303536:- | -0.25 | -3.93 | 9.76E-5 | Progressive supranuclear palsy |
| THCA | cis | rs6547741 | 1 | rs6547734 | chr2:27830990 | FNDC4 | chr2:27714751-27718126:- | -0.15 | -3.64 | 0.000306 | Oral cavity cancer |
| THCA | cis | rs6547741 | 1 | rs6547740 | chr2:27854369 | ZNF512 | chr2:27805893-27858101:+ | -0.14 | -3.44 | 0.000635 | Oral cavity cancer |
| THCA | cis | rs4372836 | 1 | rs6547872 | chr2:28978074 | PPP1CB | chr2:28974612-29025805:+ | 0.17 | 4.24 | 2.68E-5 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs6547872 | chr2:28978074 | TRMT61B | chr2:29072690-29093175:- | -0.52 | -10.52 | 2.1E-23 | Body mass index |
| THCA | cis | rs7631605 | 1 | rs6550450 | chr3:37123099 | EPM2AIP1 | chr3:37027358-37034795:- | 0.13 | 3.94 | 9.51E-5 | Cerebrospinal P-tau181p levels |
| THCA | cis | rs7631605 | 1 | rs6550450 | chr3:37123099 | LRRFIP2 | chr3:37094117-37217851:- | 0.5 | 13.83 | 8.11E-37 | Cerebrospinal P-tau181p levels |
| THCA | cis | rs2639990 | 1 | rs655156 | chr18:72898181 | ZADH2 | chr18:72909279-72921281:- | 0.3 | 4.89 | 1.36E-6 | Vascular endothelial growth factor levels |
| THCA | cis | rs2412488 | 1 | rs6554100 | chr4:54240108 | SCFD2 | chr4:53739152-54232242:- | 0.2 | 3.82 | 0.000154 | DNA methylation (variation) |